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[Evaluation of D-dimer levels in obliterating arteriopathies]
V Petruzzellis1, M T Ventura, T Florio
1Clinica dermatologica, Università, Bari.
Insights
Elevated D-dimer levels are significantly higher in patients with chronic obliterating arteriopathy of the lower limbs. This finding highlights D-dimer
Area of Science:
- Vascular Medicine
- Hematology
- Biochemistry
Background:
- Chronic obliterating arteriopathy of the lower limbs (COALL) is a significant vascular disease.
- Assessing biomarkers for COALL progression and complications is crucial for patient management.
Purpose of the Study:
- To evaluate D-dimer serum levels in patients with COALL.
- To investigate the correlation between D-dimer levels and disease severity.
- To explore the relationship between D-dimer and LDL cholesterol in COALL patients.
Main Methods:
- Enzyme-Linked Immunosorbent Assay (ELISA) technique used for D-dimer quantification.
- Study included 30 male patients with second and third-stage COALL and a matched control group.
- D-dimer levels assessed at 1:200 and 1:500 dilutions.
Main Results:
- Significantly higher D-dimer serum levels were observed in COALL patients compared to controls.
- A clear correlation was found between D-dimer levels and the extent of arteriopathy.
- A significant correlation was identified between D-dimer and LDL cholesterol levels in COALL patients.
Conclusions:
- D-dimer is a valuable biomarker in chronic obliterating arteriopathy of the lower limbs.
- Elevated D-dimer levels correlate with disease severity and may indicate increased thrombotic activity.
- Monitoring D-dimer may aid in preventing trophic lesions through early thrombolytic therapy.
Abstract:
A research has been carried out for the evaluation of D-dimer serum levels by the ELISA technique at 1:200 and 1:500 dilution in 30 male patients suffering from chronic obliterating arteriopathy of the lower limbs at second and third stage of the disease and in a homogeneous control group for number, sex and age. The value difference between the two groups, for both dilutions, seems to be highly significant with higher levels in the arteriopathic patients. The extent of D-dimer levels has shown an obvious correlation in respect to the entity of the arteriopathy. It has been also observed a significant correlation between the D-dimer and LDL levels in the arteriopathic patients. The usefulness of such a parameter in order to prevent trophic lesions in the obliterating arteriopathy is emphasized for the possibility of establishing an early and prolonged thrombolytic therapy.