A Population-based study of Toenail onychomycosis in Israeli children

Vera Leibovici1, Ruth Evron, Milka Dunchin

  • 1Department of Dermatology, Hadassah University Hospital, Jerusalem, Israel. doctor_ima@yahoo.com

Pediatric Dermatology
|March 3, 2009
PubMed

Insights

Toenail onychomycosis, a fungal nail infection, is increasingly found in children. This study surveyed Israeli schoolchildren, revealing a low prevalence but highlighting age-related increases and common causative fungi.

Area of Science:

  • Dermatology
  • Mycology
  • Pediatrics

Background:

  • Onychomycosis is common in adults but historically considered rare in children.
  • Recent studies indicate a rising prevalence of toenail onychomycosis in pediatric populations.
  • Population-based data on childhood onychomycosis remain limited.

Purpose of the Study:

  • To conduct a comprehensive, population-based survey of toenail onychomycosis prevalence in primary school children in Israel.
  • To identify predisposing factors and etiological agents of onychomycosis in this age group.

Main Methods:

  • A cross-sectional survey involving 1148 primary school children (aged 5-14) in the Jerusalem vicinity.
  • Physical examinations and personal questionnaires to gather data on predisposing factors.
  • Prevalence calculation and analysis of demographic and etiological data.

Main Results:

  • The overall prevalence of toenail onychomycosis was found to be 0.87%.
  • Prevalence demonstrated an increase with age, with a boy/girl ratio of 2.2.
  • The primary etiological agents identified were Trichophyton rubrum, followed by Trichophyton mentagrophytes and Candida albicans.

Conclusions:

  • Despite a low overall prevalence, toenail onychomycosis is present in Israeli schoolchildren.
  • Findings suggest transmission from adults to children, likely through environmental contact.
  • Onychomycosis should be considered in the differential diagnosis of pediatric nail abnormalities.

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...