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Published on: October 7, 2014
Gene expression profiling in anti-CD11d mAb-treated spinal cord-injured rats
Paul Gris1, Allyson Tighe, Sakina Thawer
1The Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, London, Canada.
Abstract:
Acute administration of a mononclonal antibody (mAb) raised against the CD11d subunit of the leukocyte CD11d/CD18 integrin after spinal cord injury (SCI) in the rat greatly improves neurological outcomes. We have profiled gene expression in anti-CD11d and isotyped-matched control mAb-treated rats after SCI. Microarray analysis demonstrated reduced expression of pro-inflammatory cytokines and increased expression of inflammatory mediators that promote wound healing and the expression of scar proteins predicted to improve nerve growth. These changes in gene expression may reflect changes in the types of macrophages that populate the lesions in anti-CD11d mAb-treated rats.