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Updated: Jun 25, 2026
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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Gated irradiation with scanned particle beams
Christoph Bert1, Alexander Gemmel, Nami Saito
1Gesellschaft für Schwerionenforschung, Abt. Biophysik, Darmstadt, Germany. c.bert@gsi.de
Summary
Increased overlap of scanned particle beams effectively reduces interplay effects from target motion during gated radiation therapy. This strategy enhances dose accuracy in charged particle therapy, improving treatment outcomes.
Area of Science:
- Medical Physics
- Radiation Oncology
- Particle Therapy
Background:
- Gated delivery in scanned particle beam therapy is challenged by interplay effects between beam scanning and residual target motion.
- These effects can lead to dose inaccuracies, impacting treatment efficacy.
Purpose of the Study:
- To investigate methods for mitigating interplay effects in scanned particle beam therapy.
- To demonstrate the effectiveness of increased pencil beam overlap in managing target motion within a gating window.
Main Methods:
- Simulations and experimental validation were used for scanned carbon ion beams.
- Lateral overlap was increased by adjusting pencil beam widths and scan grid spacing.
- Longitudinal overlap was enhanced by reducing iso-range slice distances.
Main Results:
- Local dose deviations were kept below 5% for various residual lateral motions with optimized parameters.
- Reduced iso-range slice distance effectively managed significant range changes.
- Simulation predictions were confirmed by experimental data.
Conclusions:
- Increasing lateral and longitudinal overlap of pencil beams is an effective strategy.
- This approach significantly decreases interplay effects between gated beam delivery and target motion.
- The findings support improved dose precision in charged particle therapy.
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