[Mastenbroek controversy or how much ink is spilled on preimplantation genetic screening subject]

Preimplantation genetic screening (PGS) of in vitro fertilization (IVF) embryos has been used for advanced maternal age, repeated miscarriages and repeated implantation failure indications. Several non-randomized studies have been published, showing increased implantation rates, decreased miscarriages and trisomy rates. So PGS seemed to improve prognosis for this particular population. In 2004, a prospective randomized study tempered those results, being unable to demonstrate any significant difference of live birth rate with and without PGS in case of advanced maternal age. In July 2007, another multicenter randomized double-blind trial definitely reopened the controversy, reporting that PGS did not increase but instead significantly reduced pregnancy and live birth rates after IVF in women 35 years of age or older. The debate about efficiency and usefulness of PGS is ongoing and other powered randomized studies will be needed to conclude about real PGS usefulness.