Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bithiophene Scaffold for PET Imaging and Photosensitization as a Novel Theranostic Platform Targeting Amyloid-β Aggregates.

ACS chemical neuroscience·2026
Same author

Systematic Investigation of Fatty Acids with Different Carbon-Chain Length as Albumin Binder to Improve Tumor Accumulation of Radioligands.

Bioconjugate chemistry·2026
Same author

Head-to-Head Comparison of Monomeric, Homodimeric, and Heterodimeric Fibroblast Activation Protein-Targeting Radioligands Based on Small Molecule Inhibitor and Cyclic Peptide.

ACS pharmacology & translational science·2026
Same author

Development of Novel Cholecystokinin 2 Receptor-Targeted Radioligand Containing Albumin Binder for Efficient <sup>111</sup>In/<sup>177</sup>Lu Theranostics.

Bioconjugate chemistry·2026
Same author

Engagement of the TCR against an oncolytic virus generates a population of effector CAR T cells with potent antitumor activity.

Science advances·2026
Same author

In Situ Analytical Chemistry Laboratory for the Exobiology Extant Life Surveyor.

ACS measurement science au·2026
Same journal

[Fragment Molecular Orbital Calculation Analysis of Influenza Neuraminidase and Inhibitor Interactions].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2026
Same journal

Pharmacist Intervention Preventing Severe Cytokine Release Syndrome Induced by Immune Checkpoint Inhibitor Therapy: A Case Report.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2026
Same journal

[Pulmonary Arterial Hypertension Impairs Duodenal Barrier Integrity in Rats].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2026
Same journal

[Impact of In-Hospital Emergency Call Participation on Pharmacists' Professionalism and Psychological Stress].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2026
Same journal

[Aging and Proteostasis].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2026
Same journal

[The Six-year Education Program at the School of Pharmaceutical Science, The University of Osaka Designed to Enhance Drug Development].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

[Molecular imaging by PET/SPECT].

Masahiro Ono1

  • 1Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan. ono@pharm.kyoto-u.ac.jp

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|March 3, 2009
PubMed
Summary
This summary is machine-generated.

Molecular imaging using PET/SPECT and radiopharmaceuticals offers sensitive, noninvasive evaluation of physiological functions and disease biomarkers. Ongoing research focuses on developing novel radiopharmaceuticals for improved diagnostics in oncology and neurodegenerative diseases like Alzheimer's.

More Related Videos

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
09:08

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method

Published on: December 20, 2024

Whole-body PET/MRI of Pediatric Patients: The Details That Matter
10:02

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

Related Experiment Videos

Last Updated: Jun 25, 2026

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
09:08

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method

Published on: December 20, 2024

Whole-body PET/MRI of Pediatric Patients: The Details That Matter
10:02

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

Area of Science:

  • Nuclear medicine
  • Radiochemistry
  • Biomedical imaging

Background:

  • Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) are crucial molecular imaging modalities.
  • Radiopharmaceuticals enable noninvasive, quantitative assessment of physiological processes, gene expression, and receptor distribution.
  • The development of advanced imaging equipment enhances the potential of PET/SPECT in medical science and clinical diagnostics.

Purpose of the Study:

  • To review recent advancements in radiopharmaceuticals for PET/SPECT imaging.
  • To highlight the application of radiopharmaceuticals in diagnosing various diseases, including cancer and Alzheimer's disease.
  • To discuss the development of novel probes targeting in vivo biomarkers.

Main Methods:

  • Review of current literature on radiopharmaceutical development for PET/SPECT.
  • Analysis of radiopharmaceuticals used in clinical diagnosis, such as (18)F-2-fluoro-2-deoxyglucose ([(18)F]FDG).
  • Exploration of emerging radiotracers targeting specific biomarkers for diseases like cancer and Alzheimer's.

Main Results:

  • [(18)F]FDG is a widely used radiopharmaceutical for cancer diagnosis, providing information on malignancy and metastasis.
  • Radiopharmaceuticals based on proteins and peptides show promise for diagnosing tumors, arteriosclerosis, and thrombus.
  • Development of low-molecular-weight probes for quantifying beta-amyloid plaques and neurofibrillary tangles in Alzheimer's disease is an active research area.

Conclusions:

  • Molecular imaging with PET/SPECT and radiopharmaceuticals is vital for understanding physiological and pathological functions.
  • Continued development of targeted radiopharmaceuticals is essential for improving diagnostic accuracy and therapeutic strategies.
  • Future research will likely focus on novel probes for early and precise diagnosis of complex diseases.