Nanoscale live-cell imaging using hopping probe ion conductance microscopy

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Pavel Novak1, Chao Li, Andrew I Shevchuk

  • 1Imperial College London, UK.

Nature Methods
|March 3, 2009
PubMed

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The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...