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Updated: Jun 25, 2026
An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy
Published on: January 25, 2019
Bimanual technique in proliferative diabetic retinopathy using an optical fiber-free intravitreal surgery system: a
Li-Jun Shen1, Zhao-Yang Wang, Jia Qu
1The School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang - China.
Purpose:
To evaluate the results of bimanual membrane peeling technique with an optical fiber-free intravitreal surgery system (OFFISS) in eyes with fibrovascular proliferation due to diabetic retinopathy.
Methods:
Fifteen eyes of 14 consecutive patients with severe fibrovascular proliferation due to diabetic retinopathy who underwent bimanual vitrectomy using the OFFISS and 15 eyes of 15 nonconsecutive patients with similar fundus condition who underwent vitrectomy using a conventional microscope system were compared in a retrospective, consecutive case control series.
Results:
Reattachment rates at 3 months following surgery for the cases and controls were 93% and 100%, respectively, and final reattachment rates for both were 100%. The best corrected visual acuity improved by two lines or more in 100% of the cases as compared to 87% of the controls (p=0.48). The mean VA (logMAR) improved 1.08 in the cases and 0.93 in the controls at final examination (p=0.46). Surgical complications were rare in both groups (p>0.05). The mean duration of membrane peeling of the cases was significantly lower than the controls (p=0.01).
Conclusions:
For complicated surgical manipulations such as membrane peeling in diabetic vitrectomy for severe fibrovascular proliferation, bimanual vitrectomy using the OFFISS is a more effective and safer alternative to the conventional vitrectomy method.
