Related Experiment Video
Updated: Jun 25, 2026

07:44
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Three-dimensional imaging of an optic disk pit using high resolution optical coherence tomography.
Miklos Schneider1, Wolfgang Geitzenauer, Christian Ahlers
1Department of Ophthalmology and Optometry, Medical University Vienna, Vienna - Austria. schneider@szem1.sote.hu
European Journal of Ophthalmology
|March 3, 2009
Summary
High-resolution optical coherence tomography (OCT) revealed a connection between intraretinal and subretinal spaces in an optic disc pit. This finding suggests subarachnoid fluid may cause retinal detachment and vision loss.
Area of Science:
- Ophthalmology
- Medical Imaging
Background:
- Optic disc pits are congenital abnormalities that can lead to visual disturbances.
- The exact mechanism of fluid accumulation in optic disc pits remains unclear.
Observation:
- High-resolution optical coherence tomography (OCT) was utilized to examine a patient with an optic disc pit.
- Three-dimensional segmentation was performed to analyze the structural integrity of the optic nerve head and retina.
Findings:
- OCT imaging demonstrated a potential communication pathway between the subretinal and intraretinal spaces in the affected eye.
- This suggests that fluid from the subarachnoid space may ingress into the intraretinal layers.
Implications:
- The study proposes that fluid accumulation can create a tearing force, potentially leading to outer neurosensory layer damage.
- Secondary serous retinal detachment and subsequent vision loss are hypothesized consequences.
- Advanced OCT technology, coupled with specialized software, offers detailed visualization of optic nerve and retinal microstructural changes.

