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Updated: Jun 25, 2026
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Clinical analysis of 10 cases of olfactory neuroblastoma]
Hua-Lin Wang1, Guo-Kang Fan, Zhi-Hong Lin
1Department of Otolaryngology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Objective:
To review the diagnosis, treatment and prognosis of olfactory neuroblastoma.
Methods:
Clinical data were retrospectively reviewed in 10 cases of olfactory neuroblastoma admitted from 1998 to 2002, including data of transmission electron microscopic (TEM) observation in 4 cases. According to Kadish's classification, 2 cases were in stage A, 4 in stage B and 4 in stage C. Three patients were treated with surgery alone, 7 with combined surgery and radiation.
Result:
Among 10 cases, the overall 5-year survival rate was 60 %(6/10); 3 patients died from local recurrence, 1 lost follow-up. TEM demonstrated granules in the cytoplasm of 3 patients.
Conclusion:
The combined surgery and radiation can achieve excellent local control. Transmission electron microscope is important for its diagnosis.
