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Updated: Jun 25, 2026

An Improved Technique for Trimethylamine Detection in Animal-Derived Medicine by Headspace Gas Chromatography-Tandem Quadrupole Mass Spectrometry
Published on: March 10, 2023
[Determination of melamine residue in foods using gas chromatography-tandem mass spectrometry]
Yeju Lu1, Yong Shu, Chengshi Zhao
1National Center for Quality Supervision and Test of Agricultural-Avocation Processed Food, Hefei 230051, China. luyeju998@sina.com
Abstract:
A method of gas chromatography-tandem mass spectrometry (GC-MS/MS) was developed for melamine residue in foods. The sample was extracted under ultrasonication with trichloroacelic acid (TCA), the protein in the sample was precipitated with zinc acetate solution. The extract was centrifuged, filtered, purified, derivatized and detected using GC-MS/MS in multiple-reaction monitoring mode. The limit of detection for melamine was 1 microg/kg. The good linearity in the range of 0.1 - 100 microg/L was obtained. The relative standard deviation (RSD) of peak area was less than 9%. This method has been applied to the analysis of melamine in milk powder, toffee, milk beverages, biscuits and other foods. It provides a method for the detection of abuse of melamine.
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