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Updated: Jun 25, 2026

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
Published on: April 30, 2020
[Left ventricular remodeling in outpatients with chronic renal failure treated with hemodialysis]
Aim:
To study left ventricular remodeling (LVR) in patients with end-stage renal disease (ESRD) treated by hemodialysis (HD).
Material And Methods:
A total of 122 patients with ESRD were examined: 21 patients with predialysis ESRD (group 1), 37 patients treated by HD for 4 hours thrice a week (group 2), 64 patients treated by HD for 5 hours thrice a week (group 3). All the patients have undergone echocardiography. Blood serum hemoglobin, urea, creatinine, albumin, calcium, phosphates, PTH were measured. URR and Kt/ V were calculated in patients of group 2 and 3.
Results:
LVM and ILVM were significantly higher in patients of group 2, excentric geometry predominated (63.2%).
Conclusion:
Prolongation of HD procedure from 4 to 5 hours thrice a week positively influences left ventricular remodeling and increases the survival of ESRD patients treated by HD.
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Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...