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Updated: Jun 25, 2026
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Translating pathology in multiple sclerosis: the combination of postmortem imaging, histopathology and clinical
A Seewann1, E-J Kooi, S D Roosendaal
1Department of Neurology, VU University Medical Centre, MS Centre Amsterdam, Amsterdam, The Netherlands.
Background:
Studies combining postmortem magnetic resonance imaging (MRI) and histopathology have provided important insights into the abnormalities reflected by MRI.
Materials And Methods:
A short overview of these studies applied to multiple sclerosis (MS) is provided in this review, and the Amsterdam postmortem imaging protocol is specifically highlighted.
Conclusion:
Postmortem MRI and histopathology correlation studies have enabled a direct translation of basic pathology in MS to the clinical setting, and have simultaneously served as a biological validation of new MRI techniques.
Insights
Postmortem MRI and histopathology studies offer direct insights into multiple sclerosis (MS) pathology. This review highlights how these correlations validate new MRI techniques for clinical use.
Area of Science:
- Neuroimaging
- Pathology
- Multiple Sclerosis Research
Background:
- Combining postmortem magnetic resonance imaging (MRI) with histopathology provides crucial insights into MRI-detectable abnormalities.
- Previous research has established the value of correlating imaging findings with tissue examination.
Purpose of the Study:
- To review studies correlating postmortem MRI and histopathology in multiple sclerosis (MS).
- To highlight the Amsterdam postmortem imaging protocol within this context.
- To emphasize the translational and validation aspects of these correlative studies.
Main Methods:
- Review of existing literature on postmortem MRI and histopathology in MS.
- Specific focus on the Amsterdam postmortem imaging protocol.
- Analysis of how these methods contribute to understanding MS pathology.
Main Results:
- Correlation studies reveal direct links between basic MS pathology and clinical manifestations.
- Postmortem MRI-histopathology correlations serve as a biological validation for novel MRI techniques.
- The Amsterdam protocol is presented as a key methodology in this field.
Conclusions:
- Postmortem MRI-histopathology correlation is essential for translating basic MS pathology to clinical practice.
- These studies validate the biological underpinnings of advanced MRI techniques.
- This approach enhances the understanding and diagnostic capabilities for multiple sclerosis.
