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Updated: Jun 25, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Published on: August 22, 2022

Edentulism and comorbid factors.

David A Felton¹

¹Department of Prosthodontics, University of North Carolina School of Dentistry, Chapel Hill, NC 27599, USA. dave_felton@dentistry.unc.edu

Journal of Prosthodontics : Official Journal of the American College of Prosthodontists

|March 4, 2009

Summary

This summary is machine-generated.

Complete edentulism, the loss of all teeth, is linked to increased risks of poor nutrition, smoking, diabetes, and certain cancers. Further research is needed to understand the causal relationship between these comorbidities and edentulism.

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Last Updated: Jun 25, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Published on: August 22, 2022

Area of Science:

Oral Health
Geriatric Health
Public Health

Background:

Complete edentulism is a significant global health burden resulting from multifactorial causes.
It represents the terminal stage of dental disease and impacts a growing patient population.
Understanding comorbid factors associated with edentulism is crucial for comprehensive patient care.

Purpose of the Study:

To identify and review existing comorbid conditions associated with complete edentulism.
To synthesize current literature on the health status of completely edentulous individuals.

Main Methods:

A comprehensive literature review was conducted using PubMed.
Keywords included 'edentulism' combined with terms for various health conditions and risk factors.
Articles were screened for relevance, and full-text reviews focused on studies with adequate patient cohorts and minimum 2-year follow-up.

Main Results:

Completely edentulous patients exhibit higher risks for poor nutrition, cardiovascular disease (OR 2.32), smoking (OR 2.42), asthma (OR 10.52), diabetes (OR 1.82), rheumatoid arthritis (OR 2.27), and certain cancers (ORs 1.54-2.85).
Chronic residual ridge resorption remains the primary intraoral complication following tooth loss.
Edentulism is a global issue with increasing demand for complete denture prostheses projected for the future.

Conclusions:

Completely edentulous patients are associated with an increased risk of multiple systemic disorders.
The causal or casual nature of these associations requires further investigation.
Optimal complete denture therapy and regular follow-up are essential to mitigate residual ridge loss.