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Related Concept Videos

Quality Control01:05

Quality Control

Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
Quality Assurance01:19

Quality Assurance

Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: Jun 25, 2026

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
06:42

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications

Published on: September 2, 2025

Breast cancer quality control.

Cam Patterson1, Sarah Ronnebaum

  • 1Division of Cardiology and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, North Carolina 27599-7126, USA. cpatters@med.unc.edu

Nature Cell Biology
|March 4, 2009
PubMed
Summary
This summary is machine-generated.

A cytoplasmic protein quality-control pathway suppresses breast cancer cell growth. This finding suggests a novel role for cellular quality control in preventing malignant cell development.

Related Experiment Videos

Last Updated: Jun 25, 2026

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
06:42

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications

Published on: September 2, 2025

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Tumorigenesis involves complex regulatory mechanisms including cell signaling, transcription, and DNA replication.
  • The role of cellular quality control in cancer suppression is an emerging area of investigation.

Purpose of the Study:

  • To investigate the role of cytoplasmic protein quality-control pathways in regulating breast cancer cell growth.
  • To identify new mechanisms by which cellular quality control can suppress malignant potential.

Main Methods:

  • Analysis of cytoplasmic protein levels and function in breast cancer cells.
  • Investigating the impact of protein quality-control pathway modulation on cell proliferation.
  • Utilizing cell-based assays to assess malignant characteristics.

Main Results:

  • A specific cytoplasmic protein quality-control pathway was found to be active in suppressing breast cancer cell proliferation.
  • Disruption of this pathway led to increased breast cancer cell growth.
  • The findings implicate protein quality control as a critical factor in preventing the development of malignant cells.

Conclusions:

  • Cytoplasmic protein quality-control pathways represent a novel mechanism for suppressing breast cancer cell growth.
  • These pathways hold potential as therapeutic targets for breast cancer intervention.
  • Cellular quality control plays a significant role in tumor suppression, extending beyond traditional regulatory pathways.