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Related Concept Videos

Effects of Chemicals: Overview01:27

Effects of Chemicals: Overview

Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
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Chemical Reactions

A chemical reaction is a process by which the bonds in the atoms of substances are rearranged to generate new substances. Matter cannot be created or destroyed in a chemical reaction—the same type and number of atoms that make up the reactants are still present in the products. Merely, the rearrangement of chemical bonds produces new compounds.
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The protons in unsubstituted alkanes are strongly shielded with chemical shifts below 1.8 ppm. Methine, methylene, and methyl protons appear at approximately 1.7, 1.2 and 0.7 ppm, while the proton signal from methane appears at 0.23 ppm. An electronegative substituent, such as chlorine, withdraws the electron density from the protons, increasing their chemical shift. Progressive substitution of the hydrogens in methane by chlorine shifts the proton signals increasingly downfield, to 3.05 ppm in...
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Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
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Combinatorial chemistry: oh what a decade or two can do.

Walter H Moos1, Clarence R Hurt, Guillermo A Morales

  • 1SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA. walter.moos@sri.com

Molecular Diversity
|March 4, 2009
PubMed
Summary
This summary is machine-generated.

This commentary explores the origins and future of combinatorial chemistry and molecular diversity. It highlights key journals, books, and pioneers that shaped these scientific fields.

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Area of Science:

  • Medicinal Chemistry
  • Drug Discovery
  • Chemical Synthesis

Background:

  • The commentary reviews the foundational period of combinatorial chemistry and molecular diversity.
  • It traces the evolution of these fields from their inception.

Purpose of the Study:

  • To provide a historical perspective on combinatorial chemistry and molecular diversity.
  • To discuss the future trajectory of these scientific disciplines.

Main Methods:

  • A high-level review of the literature, including journals and books.
  • Identification of key pioneers and significant advances in the field.

Main Results:

  • The early development of combinatorial chemistry and molecular diversity was influenced by specific publications and researchers.
  • The field has evolved significantly since its beginnings.

Conclusions:

  • Combinatorial chemistry and molecular diversity have laid the groundwork for modern drug discovery.
  • Continued innovation in these areas is expected to drive future scientific advancements.