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Related Experiment Video

Updated: Jun 25, 2026

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

Transverse field effects on DNA-sized particle dynamics.

Makusu Tsutsui¹, Masateru Taniguchi, Tomoji Kawai

¹The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan.

|March 5, 2009

Summary

This summary is machine-generated.

We developed a microfluidics device to study DNA particle movement. Electrostatic forces slow particle flow, showing electric fields can control particle passage through nanopores.

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Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

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Magnetic Tweezers for the Measurement of Twist and Torque

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Published on: May 19, 2014

Area of Science:

Nanotechnology
Biophysics
Microfluidics

Background:

Microfluidic devices are crucial for manipulating and analyzing nanoscale particles.
Understanding particle dynamics in confined spaces is essential for applications like DNA sequencing.
Mechanically controllable break junctions (MCBJs) offer precise control over nanoscale gaps.

Purpose of the Study:

To develop a microfluidics-integrated MCBJ device for electrical characterization.
To investigate the dynamics of DNA-sized particles within microfluidic channels.
To explore the influence of electrostatic interactions on particle translocation.

Main Methods:

Fabrication of a microfluidics-integrated mechanically controllable break junction.
Electrical characterization of DNA-sized particle dynamics.
Application of transverse electric fields to control particle flow.

Main Results:

The developed device successfully enabled electrical characterization of particle dynamics.
Electrostatic interactions between electrodes and particles were observed to impede particle flow.
Particle flow was significantly slowed down within the electrode nanogaps.

Conclusions:

The microfluidics-integrated MCBJ is a viable tool for studying nanoscale particle behavior.
Electrostatic forces play a significant role in modulating particle translocation dynamics.
Transverse electric fields demonstrate potential for controlling DNA translocation through nanopores.