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Updated: Jun 25, 2026

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
Published on: January 15, 2013
Ultrahigh-resolution versus speckle noise-reduction in spectral-domain optical coherence tomography
Masanori Hangai1, Motoshi Yamamoto, Atsushi Sakamoto
1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shougoin, Sakyo-ku, Kyoto 606-8507, Japan. hangai@kuhp.kyoto-u.ac.jp
Abstract:
Ultrahigh-resolution (UHR) spectral-domain optical coherence tomography (SD-OCT) and speckle noise-reduced SD-OCT instruments were compared with regard to their ability to visualize retinal microstructures and detect micropathologies in the same series of eyes in this hospital-based study. Both the instruments identically visualized normal retinal structures, except for the retinal ganglion cell layer, which was better delineated by the speckle noise-reduced SD-OCT instrument. Retinal pigment epithelium (RPE) and Bruch's membrane were better delineated by UHR SD-OCT. Retinal and sub-RPE pathologies were also identically visualized by both the instruments. Layer differentiation for locating each pathology was better visualized by speckle noise-reduced SD-OCT.
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