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Updated: Jun 25, 2026
Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
Published on: March 18, 2015
Defining the potential for cell therapy for vascular disease using animal models
Rajiv Gulati1, Robert D Simari
1Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
Abstract:
Cell-based therapeutics are currently being developed for a wide array of unmet medical needs. As obstructive vascular disease is the major cause of mortality in the world, cell-based strategies aimed at developing novel therapies or improving current therapies are currently under study. These studies are based on the evolving understanding of the biology of vascular progenitor cells, which has in turn led to the availability of well-defined sources of vascular cells for delivery. Crucial to the development of these approaches is the preclinical testing of cell delivery in animal models. This review highlights the crucial steps involved in the selection of cell sources and generation, delivery approaches, animal models to be used, and endpoints to be studied, in the context of cell delivery for vascular disease. Furthermore, the development of cell delivery to induce angiogenesis in ischemic limbs and to improve the response to large vessel injury will be discussed.
Insights
Cell-based therapies show promise for vascular diseases. This review guides preclinical testing of cell delivery for conditions like obstructive vascular disease and ischemic limbs.
Area of Science:
- Regenerative Medicine
- Cardiovascular Research
Background:
- Obstructive vascular disease is a leading global cause of mortality.
- Cell-based therapies offer novel treatment strategies for vascular conditions.
- Advances in vascular progenitor cell biology enable new therapeutic approaches.
Purpose of the Study:
- To review critical aspects of cell delivery for vascular disease treatment.
- To guide the selection of cell sources, delivery methods, and animal models.
- To discuss endpoints for evaluating cell-based vascular therapies.
Main Methods:
- Literature review of cell-based therapeutic strategies for vascular disease.
- Analysis of preclinical testing methodologies in animal models.
- Discussion of cell source selection, generation, and delivery techniques.
Main Results:
- Highlights key considerations for preclinical cell delivery studies.
- Emphasizes the importance of appropriate animal models and outcome measures.
- Discusses applications in inducing angiogenesis and improving large vessel injury response.
Conclusions:
- Optimizing cell delivery is crucial for effective vascular disease therapeutics.
- Preclinical evaluation guides the translation of cell-based therapies.
- Further research is needed to refine cell delivery for vascular regeneration and repair.
