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Updated: Jun 25, 2026
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Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
Published on: March 18, 2015
Defining the potential for cell therapy for vascular disease using animal models
Rajiv Gulati1, Robert D Simari
1Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
Disease Models & Mechanisms
|March 5, 2009
Summary
Cell-based therapies show promise for vascular diseases. This review guides preclinical testing of cell delivery for conditions like obstructive vascular disease and ischemic limbs.
Area of Science:
- Regenerative Medicine
- Cardiovascular Research
Background:
- Obstructive vascular disease is a leading global cause of mortality.
- Cell-based therapies offer novel treatment strategies for vascular conditions.
- Advances in vascular progenitor cell biology enable new therapeutic approaches.
Purpose of the Study:
- To review critical aspects of cell delivery for vascular disease treatment.
- To guide the selection of cell sources, delivery methods, and animal models.
- To discuss endpoints for evaluating cell-based vascular therapies.
Main Methods:
- Literature review of cell-based therapeutic strategies for vascular disease.
- Analysis of preclinical testing methodologies in animal models.
- Discussion of cell source selection, generation, and delivery techniques.
Main Results:
- Highlights key considerations for preclinical cell delivery studies.
- Emphasizes the importance of appropriate animal models and outcome measures.
- Discusses applications in inducing angiogenesis and improving large vessel injury response.
Conclusions:
- Optimizing cell delivery is crucial for effective vascular disease therapeutics.
- Preclinical evaluation guides the translation of cell-based therapies.
- Further research is needed to refine cell delivery for vascular regeneration and repair.
