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Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

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Porous pellets as drug delivery system.

A Cosijns¹, D Nizet, I Nikolakakis

¹Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

Drug Development and Industrial Pharmacy

|March 5, 2009

Summary

This study developed porous pellets for drug delivery. Immersion and supercritical fluid impregnation effectively loaded drugs throughout the porous structure, unlike surface-only layering.

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Area of Science:

Pharmaceutical Technology
Materials Science

Background:

Multiparticulate drug delivery systems offer advantages over single-unit dosage forms.
Pellets are a common multiparticulate system.

Purpose of the Study:

To develop porous pellets for drug delivery.
To evaluate drug loading techniques for these porous pellets.

Main Methods:

Porous microcrystalline pellets were fabricated using Avicel PH 101 and NaCl via extrusion/spheronization.
NaCl was extracted to create porosity (33.2%).
Drug loading was assessed using immersion in metoprolol tartrate solution, supercritical fluid impregnation with ibuprofen, and fluidized bed coating with paracetamol.

Main Results:

Raman spectroscopy confirmed drug penetration into the porous structure via immersion and supercritical fluid impregnation.
Drug incorporation efficiency correlated with drug solubility in the loading solvent.
Drug release from the porous pellets was immediate and diffusion-controlled.

Conclusions:

The developed method is suitable for producing porous pellets.
Immersion and supercritical fluid impregnation achieved uniform drug distribution within the pellets.
Fluidized bed layering resulted in drug deposition only on the pellet surface.