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Updated: Jun 25, 2026

Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking
Joshua A Sonnen1, Eric B Larson, Shelly L Gray
1Department of Pathology, University of Washington, Seattle, USA. jsonnen@u.washington.edu
Abstract:
Evidence supports a pathogenic role for free radical injury to brain in Alzheimer's disease; however, clinical trial results are only mildly encouraging. Examining brains from The Adult Changes in Thought study offers a unique perspective. Selectively increased free radical damage to cerebral cortex was associated with Alzheimer's disease, microvascular brain injury, and current smoking, but not with antioxidant supplement usage. Our results support suppression of free radical injury to brain as a therapeutic target for Alzheimer's disease and microvascular brain injury; however, future clinical trials should consider other antioxidants or doses than those identified in our study.
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