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Published on: June 26, 2018
[Experimental study on antitumor effect of extracts from Cestrum nocturnum in vivo]
Zhen-Guo Zhong1, Shi-Yuan Zhao, Jin-Yan Lv
1New Drug Development Center of University of Traditional Chinese Medicine, Nanning 530001, China. zhongzg@gxtcmu.edu.cn
Objective:
To observe the antitumor effects of extracts from Cestrum nocturnum (CN) in vivo.
Methods:
The S180-mice model was used to observe the tumor-inhibition rate of CN and the H22-mice model was used to test the survival time.
Results:
The experiment in S180-mice demonstrated that the n-butanol and polysaccharides extracts from CN had obvious effects on tumor inhibition. Its inhibitory rates were 52.30%, 46.75%, 42.28%, 43.19%, 37.96% and 31.82% respectively in the mice administrated the n-butanol and polysaccharides extracts from CN with 30 mg/kg, 20 mg/kg and 15 mg/kg weight dosage. It was noted that tumor formation postponed in mice treated with the n-butanol and polysaccharides extracts from CN compared with the control panel and tumor growth became slower; The n-butanol and polysaccharides extracts from CN could also greatly enhance the life span of mice with H22 ascitic tumors by 116.43%, 44.52%, 20.54%, 109.52%, 112.61% and 115.01%, respectively. The inhibit effects of n-butanol fraction extracts from CN had direct relationship with dose, while the polysaccharides fraction extracts from CN had no obvious relationship with dose.
Conclusion:
The n-butanol and polysaccharides extracts of CN are able to inhibit tumor growth and prolong the lifetime of the tumor-bearing mice in a dose-dependent pattern.
