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Updated: Jun 25, 2026

Isolation and Quantification of Botulinum Neurotoxin From Complex Matrices Using the BoTest Matrix Assays
Published on: March 3, 2014
Uncontrollable distant effects of botulinum neurotoxin injections
Joseph Schames1, Y Dov Prero, David Schames
1Craniofacial Pain/TMJ Clinic, White Memorial Medical Center, Los Angeles, USA.
Abstract:
Some dentists propose administering botulinum neurotoxin injections to treat orofacial pain. The scientific literature has documented there are dangerous uncontrollable effects of long-distance traveling of botulinum neurotoxin from the injection site. These distant effects are not technique-specific, not predictable, and cannot be controlled by the amount of neurotoxin, nor by the site administered. These uncontrollable distant effects of "off-label" botulinum neurotoxin injections, at the very least, must be thoroughly disclosed to patients.
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