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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

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Updated: Jun 25, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

[What is new in oncodermatology?].

C Robert1

  • 1Service de Dermatologie, Institut Gustave Roussy, Villejuif, France. caroline.robert@igr.fr

Annales De Dermatologie Et De Venereologie
|March 7, 2009
PubMed
Summary
This summary is machine-generated.

Advances in oncodermatology reveal melanoma

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Area of Science:

  • Oncodermatology
  • Melanoma Research
  • Cancer Biology

Background:

  • Melanoma research has advanced, with increased understanding of molecular pathways in distinct subtypes.
  • Molecular diversity in melanoma may explain poor clinical trial outcomes due to difficulties in patient selection for targeted therapies.

Purpose of the Study:

  • To summarize key 2023 advancements in oncodermatology, focusing on melanoma and Merkel cell carcinoma.
  • To highlight challenges and progress in melanoma treatment, including immunotherapy and targeted therapies.

Main Methods:

  • Review of recent publications in oncodermatology.
  • Analysis of findings related to melanoma subtypes, biological pathways, and clinical trial results.
  • Inclusion of significant discoveries, such as the identification of a polyomavirus linked to Merkel cell carcinoma.

Main Results:

  • Significant progress in understanding melanoma's molecular subtypes and associated biological pathways.
  • Encouraging results from adoptive immunotherapy protocols for melanoma.
  • Potential for targeted anti-Kit therapy in KIT-mutated melanomas.
  • Discovery of a defective oncogenic polyomavirus implicated in Merkel cell carcinoma.

Conclusions:

  • Melanoma's molecular complexity necessitates improved patient stratification for effective targeted therapies.
  • Adoptive immunotherapy and targeted therapies show promise for specific melanoma subsets.
  • The identification of a novel viral cause for Merkel cell carcinoma represents a major breakthrough.