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Updated: Jun 25, 2026

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
Published on: August 22, 2025
A systematic review of concomitant interventions to prevent persistent perforations following the removal of
1Department of Otolaryngology, North Cheshire Hospitals NHS Trust, Lovely Lane, Warrington, WA5 1QG, UK. jameskeir@hotmail.com
Objective:
To review the current evidence for the use of concomitant interventions to reduce the persistent perforation rate following the removal of long-term ventilation tubes.
Type Of Review:
A systematic review of the literature and meta-analysis of randomised controlled trials on this topic.
Search Strategy:
Medline (1952-2008), EMBASE (1974-2008) and the Cochrane Central Register of Controlled Trials. A combination of search terms were used in a search strategy derived from guidance from the Cochrane collaboration.
Evaluation Method:
A review of all trials by two authors with grading of the level of evidence.
Results:
Fifteen studies using a variety of interventions were identified.
Conclusion:
A multi-centre randomised controlled trial is indicated to validate findings of previous studies and elucidate any optimum intervention to reduce the persistent perforation rate.
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