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Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Imaging oncogene expression.

Archana Mukherjee1, Eric Wickstrom, Mathew L Thakur

  • 1Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Archana.Mukherjee@jefferson.edu

European Journal of Radiology
|March 7, 2009
PubMed
Summary
This summary is machine-generated.

Molecular imaging enables noninvasive genetic analysis of radiographic masses by visualizing endogenous gene expression. Further development of antisense imaging agents is needed for improved oncogene mRNA targeting.

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Area of Science:

  • Molecular biology
  • Medical imaging
  • Genetics

Background:

  • Molecular imaging is crucial for noninvasive genetic analysis.
  • Radiographic masses require advanced diagnostic tools.
  • Endogenous gene expression imaging offers new insights.

Purpose of the Study:

  • To review the importance of molecular imaging for genetic analysis.
  • To describe antisense imaging agents and hybridization probes.
  • To overview oncogene expression imaging investigations.

Main Methods:

  • Review of existing literature on molecular imaging.
  • Discussion of antisense imaging agent development.
  • Analysis of hybridization probe design for in vivo imaging.

Main Results:

  • Antisense imaging agents offer potential for noninvasive genetic analysis.
  • Challenges exist in developing effective in vivo hybridization probes.
  • Oncogene expression imaging shows promise but requires improvement.

Conclusions:

  • Further advancements in antisense-based imaging agents are necessary.
  • Improving oncogene mRNA targeting is a key future direction.
  • Molecular imaging holds significant potential for cancer diagnostics.