Biocatalysis in development of green pharmaceutical processes

Area of Science:

• Green Chemistry
• Biocatalysis
• Organic Synthesis

Background:

• Biocatalysis provides highly selective synthesis of chiral molecules in water under mild conditions.
• Enzymatic transformations avoid functional group protection/deprotection and extreme temperatures, reducing waste.
• Current chemical routes often suffer from poor efficiency and high manufacturing costs.

Purpose of the Study:

• To review novel biocatalytic pharmaceutical processes.
• To highlight the integration of enzymatic transformations into chemical synthesis at the retrosynthetic level.
• To showcase biocatalysis as a greener alternative to traditional chemical synthesis.

Main Methods:

• Literature review of biocatalytic pharmaceutical process development.
• Analysis of enzymatic transformations for regioselectivity and stereoselectivity.
• Retrosynthetic analysis for strategic integration of biocatalysis.

Main Results:

• Biocatalysis enables efficient and selective synthesis of chiral molecules.
• Enzymatic processes minimize the need for organic solvents and harsh reaction conditions.
• Novel biocatalytic routes offer improved process efficiency and reduced manufacturing costs compared to chemical methods.

Conclusions:

• Biocatalysis is a key technology for sustainable pharmaceutical manufacturing.
• Strategic integration of biocatalysis enhances green chemistry principles.
• Enzymatic processes present a viable and cost-effective alternative to conventional chemical synthesis.