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Progress in the Synthesis of Organoselenium Compounds: Conventional Routes Versus Green Approaches
Chintankumar Padariya1, Anita Kornicka1
1Department of Chemical Technology of Drugs, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.
Molecules (Basel, Switzerland)
|August 13, 2026
Summary
Organoselenium chemistry now uses green chemistry principles for safer, efficient synthesis. Sustainable methods are key for developing new organoselenium compounds with therapeutic potential.
Area of Science:
- Green Chemistry
- Medicinal Chemistry
- Organoselenium Chemistry
Background:
- Organoselenium chemistry has evolved from basic synthesis to advanced, environmentally friendly methods.
- Traditional methods often used hazardous reagents and solvents, prompting a shift towards sustainability.
Purpose of the Study:
- To review and categorize organoselenium compounds.
- To highlight advancements in synthetic methodologies, structural features, and biological activities.
- To emphasize the role of green chemistry in organoselenium compound development.
Main Methods:
- Systematic review and categorization of organoselenium compounds.
- Focus on sustainable synthetic strategies: solvent-free, aqueous, bio-based solvents, microwave-assisted, and mechanochemical techniques.
- Analysis of structural characteristics and biological activities.
Main Results:
- Sustainable methodologies offer enhanced efficiency, comparable yields, reduced waste, and improved safety.
- Green chemistry approaches align with evolving regulatory standards and safer pharmaceutical manufacturing.
- Organoselenium compounds show significant therapeutic potential.
Conclusions:
- The field of organoselenium chemistry is increasingly adopting green chemistry principles.
- Sustainable synthetic routes are crucial for the future development of organoselenium-based medicinal agents.
- Advances highlight the therapeutic promise of organoselenium compounds.
Keywords:
catalytic methodologiesgreen synthesisorganoselenium compoundssustainable chemistrytherapeutic applicationsMore Related Videos
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