Recent Advances in Synthetic Isoquinoline-Based Derivatives in Drug Design

Area of Science:

• Medicinal Chemistry
• Pharmacology
• Organic Synthesis

Background:

• Isoquinoline scaffolds exhibit a wide range of biological activities.
• Recent focus is on their anticancer properties via multiple mechanisms.
• Isoquinolines also demonstrate antimicrobial, antiviral, anti-Alzheimer, anti-inflammatory, and antidiabetic effects.

Purpose of the Study:

• To review synthetic isoquinoline derivatives and their pharmacological properties (2020-2025).
• To explore biomedical applications of these compounds.
• To highlight the potential of isoquinoline-based metal complexes in drug development.

Main Methods:

• Literature review of synthetic isoquinoline compounds.
• Analysis of their biological activities and mechanisms of action.
• Investigation of metal complexes incorporating isoquinoline ligands.

Main Results:

• Isoquinoline derivatives show significant antiproliferative effects through various pathways.
• They possess broad-spectrum antimicrobial and antiviral activities.
• Metal chelates of isoquinolines (Cu, Ir, Pt) exhibit potent biological activities.

Conclusions:

• Synthetic isoquinolines are promising candidates for novel therapeutics.
• Their metal complexes offer enhanced pharmacological properties.
• Continued research into isoquinoline derivatives will yield new biomedical applications.