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Increasing invasive disease due to penicillin resistant S. pneumoniae in India

Veeraraghavan Balaji1, Kurien Thomas, Hari Har Joshi

  • 1Department of Clinical Microbiology, Christian Medical College, Vellore, India. vbalaji@cmcvellore.ac.in

Indian Journal of Medical Sciences
|March 7, 2009
PubMed

Insights

Penicillin-intermediate resistant Streptococcus pneumoniae (S. pneumoniae) has emerged in India. This resistance may lead to more invasive pneumococcal disease and treatment failures in children and adults.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Streptococcus pneumoniae remains a significant global cause of invasive bacterial infections.
  • High rates of mortality and morbidity are associated with pneumococcal disease worldwide.

Observation:

  • Emergence of penicillin-intermediate resistance in S. pneumoniae strains detected in India.
  • Co-occurrence of multi-drug resistance patterns observed in these resistant strains.

Findings:

  • Penicillin-intermediate resistance in S. pneumoniae identified in India.
  • The resistant strains exhibit a multi-drug resistance profile.
  • This resistance pattern poses a risk for increased invasive pneumococcal disease incidence.

Implications:

  • Potential for increased clinical failure in treating invasive pneumococcal disease.
  • Need for enhanced surveillance of antimicrobial resistance in S. pneumoniae in India.
  • Urgent consideration for updated treatment guidelines and antibiotic stewardship programs.

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