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Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
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Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

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Nanostructural analysis of trabecular bone

Sun Ig Hong1, Soon Ku Hong, David H Kohn

  • 1Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109-1078, USA. sihong@cnu.ac.kr

Journal of Materials Science. Materials in Medicine
|March 7, 2009
PubMed

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
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Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
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