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Related Concept Videos

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
In vitro Mutagenesis01:16

In vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

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Related Experiment Video

Updated: Jun 25, 2026

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency
14:45

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Published on: August 6, 2014

Overview on mouse mutagenesis.

Ralf Kühn1, Wolfgang Wurst

  • 1Institute for Developmental Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Munich, Germany.

Methods in Molecular Biology (Clifton, N.J.)
|March 7, 2009
PubMed
Summary
This summary is machine-generated.

This chapter reviews mouse mutagenesis techniques developed over 20 years, offering insights into current and future strategies. It provides guidance for selecting the most effective mouse mutagenesis approach.

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Mouse Genome Engineering Using Designer Nucleases
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Mouse Genome Engineering Using Designer Nucleases

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Related Experiment Videos

Last Updated: Jun 25, 2026

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency
14:45

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Published on: August 6, 2014

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction
08:01

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

Published on: November 20, 2018

Mouse Genome Engineering Using Designer Nucleases
12:04

Mouse Genome Engineering Using Designer Nucleases

Published on: April 2, 2014

Area of Science:

  • Genetics
  • Developmental Biology
  • Animal Models

Background:

  • Mouse mutagenesis is a critical tool for understanding gene function and disease.
  • Significant advancements in mutagenesis methods have occurred over the past two decades.

Purpose of the Study:

  • To provide a comprehensive overview of the evolution of mouse mutagenesis methods.
  • To offer guidance on selecting appropriate mutagenesis strategies for research.
  • To highlight ongoing and future developments in the field.

Main Methods:

  • Review of historical and current mouse mutagenesis techniques.
  • Analysis of the progression and innovation in genetic manipulation of mice.
  • Compilation of resources for mouse mutagenesis strategies.

Main Results:

  • Detailed historical perspective on mouse mutagenesis evolution.
  • Identification of key advancements and emerging trends.
  • Practical advice for researchers on strategy selection.

Conclusions:

  • Mouse mutagenesis has undergone rapid evolution, offering powerful tools for genetic research.
  • Strategic selection of mutagenesis methods is crucial for experimental success.
  • Future developments promise even more refined approaches to mouse genetic manipulation.