Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Prescription, Nonprescription and Orphan Drugs

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...

Substance Use Disorders Affecting Sleep

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Drug Abuse and Addiction: Pharmacological Phenomena

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The impact of pain on memory: a study in chronic low back pain and migraine patients.

Brain communications·2026

Same author

Hallmarks of primary headache: part 3 - cluster headache.

The journal of headache and pain·2025

Same author

Real-World Experience of Erenumab in Patients with Migraine in Germany: The SPECTRE Study.

Pain and therapy·2024

Same author

Persistent effectiveness of CGRP antibody therapy in migraine and comorbid medication overuse or medication overuse headache - a retrospective real-world analysis.

The journal of headache and pain·2024

Same author

Effectiveness and tolerability of eptinezumab in treating patients with migraine resistant to conventional preventive medications and CGRP (receptor) antibodies: a multicentre retrospective real-world analysis from Germany.

The journal of headache and pain·2024

Same author

Cognitive deficits in patients with peripheral vestibular dysfunction.

European journal of neurology·2023

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Medication overuse headache.

Zaza Katsarava¹, Dagny Holle, Hans-Christoph Diener

¹Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, Essen, Germany. zaza.katsarava@uni-essen.de.

Current Neurology and Neuroscience Reports

|March 10, 2009

Summary

Medication overuse headache (MOH) is chronic headache caused by regular use of pain relievers. This review covers MOH epidemiology, risk factors, pathophysiology, and treatment strategies to prevent chronic headaches.

Area of Science:

Neurology
Clinical Pharmacology

Background:

Medication overuse headache (MOH) is a prevalent condition characterized by chronic headache.
It affects 3-4% of the general population globally.
Overuse of antiheadache medications is a significant cause of chronic headache, accounting for 30-50% of cases.

Purpose of the Study:

To review the current literature on the epidemiology of MOH.
To explore the risk factors and pathophysiology associated with MOH.
To summarize effective treatment and prevention strategies for headache chronicity.

Main Methods:

Literature review of studies on medication overuse headache.
Analysis of epidemiological data, risk factors, and pathophysiological mechanisms.
Synthesis of current therapeutic and preventive approaches.

More Related Videos

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

Related Experiment Videos

Last Updated: Jun 25, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

Main Results:

MOH is defined as daily or near-daily headache from overusing antiheadache drugs.
Chronic headache prevalence is significant, with a substantial proportion linked to medication overuse.
Understanding risk factors and pathophysiology is crucial for management.

Conclusions:

MOH is a growing global health concern requiring targeted interventions.
Effective management involves addressing medication overuse and preventing headache chronification.
Further research into pathophysiology may yield novel treatment strategies.