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[Pneumococcal meningitis in children in France: 832 cases from 2001 to 2007]

C Levy1, E Varon, E Bingen

  • 1GPIP (Groupe de Pathologie Infectieuse Pédiatrique) de la SFP (Société Française de Pédiatrie), 27 rue Inkermann, F94100 Saint Maur des Fossés, France. activ@activfrance.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|March 10, 2009
PubMed

Insights

Pneumococcal meningitis cases in children did not decline as expected in France due to insufficient vaccination coverage with the 7-valent pneumococcal conjugate vaccine (PCV7). However, PCV7 significantly reduced vaccine-type pneumococcal meningitis in vaccinated children.

Area of Science:

  • Pediatric Infectious Diseases
  • Vaccinology
  • Epidemiology

Context:

  • Pneumococcal meningitis is a leading cause of child mortality and morbidity in France.
  • The Groupe de Pathologie Infectieuse Pédiatrique (GPIP) and Association Clinique et Thérapeutique Infantile du Val de Marne (ACTIV) established surveillance for pneumococcal meningitis.
  • The study aimed to analyze clinical features and the impact of the 7-valent pneumococcal conjugate vaccine (PCV7).

Purpose:

  • To assess the incidence and characteristics of pneumococcal meningitis in French children.
  • To evaluate the impact of PCV7 on pneumococcal meningitis cases.
  • To identify trends in serotypes causing meningitis in vaccinated and unvaccinated children.

Summary:

  • A 7-year surveillance (2001-2007) identified 832 pneumococcal meningitis cases among 2951 bacterial meningitis cases in children aged 0-18 years.
  • No significant decline in overall pneumococcal meningitis cases was observed, with peaks incidence at 5 months.
  • In vaccinated children (2003-2007), few vaccine-type (VT) serotypes were identified, with serotype 19A being prominent in non-vaccine types.

Impact:

  • Insufficient PCV7 coverage and slow vaccine implementation likely contributed to the lack of expected decline in pneumococcal meningitis.
  • PCV7 demonstrated a clear impact by significantly reducing VT pneumococcal meningitis in vaccinated children.
  • The case fatality rate remained stable at approximately 11.4% throughout the study period.
Abstract

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