Related Experiment Video
Updated: Feb 19, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Systemic lupus erythematous revealed by an acute psychotic episode]
F Jghaimi1, A Kabbaj, L Essaadouni
1Service de médecine interne, CHU Mohammed VI, Marrakech, Maroc. jghaimi2020@hotmail.com
Introduction:
Psychotic disorders are classical in systemic lupus and are listed among American College of Rheumatology (ARA) criteria. They are rarely inaugural and can compromise diagnosis, especially if they are isolated.
Clinical Case:
A 20-old-year woman was hospitalized for an acute psychotic disorder of two weeks duration with a degradation of the general status. Physical examination revealed intense osteo-tendon reflexes with a right Babinski sign. Brain MRI visualized a nodular low signal T1, T2 and high signal T2 flair in the left centrum semi-ovale. Blood counts showed lymphopenia. Antinuclear antibody and anti-DNA native antibody were positive. The clinical course favorable after treatment using oral corticosteroids, an neuroleptic and an antidepressant.
Conclusion:
Systemic lupus is a potential diagnosis for any atypical psychiatric symptoms in young women.
Related Concept Videos
Psychosis and Antipsychotic Drugs: Overview
Psychosis: Goals of Pharmacotherapy
Schizophrenia
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Psychological and Sociocultural Causes of Schizophrenia
Mania and Antimanic Drugs: Overview

