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Related Concept Videos

Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains delta-9-tetrahydrocannabinol (THC)...
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.

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Related Experiment Video

Updated: Jun 25, 2026

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
07:30

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

Psychedelics and schizophrenia.

Javier González-Maeso1, Stuart C Sealfon

  • 1Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.

Trends in Neurosciences
|March 10, 2009
PubMed
Summary
This summary is machine-generated.

Research suggests psychedelics and antipsychotics may target a shared serotonin-glutamate receptor complex, potentially unifying schizophrenia treatment hypotheses. This could lead to novel therapeutic strategies for schizophrenia.

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Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
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Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

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Last Updated: Jun 25, 2026

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
07:30

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Psychiatry

Background:

  • Hallucinogenic drugs like lysergic acid diethylamide (LSD) and dissociative drugs such as phencyclidine (PCP) share symptom similarities with schizophrenia.
  • Atypical antipsychotic drugs often target serotonin 5-HT(2A) receptors, a key site for LSD-like drugs.

Purpose of the Study:

  • To explore the converging research between psychedelics, dissociative drugs, and schizophrenia.
  • To investigate the potential shared neurochemical targets for antipsychotic and psychedelic drugs.

Main Methods:

  • Review of existing research on drug effects and receptor affinities.
  • Identification of a serotonin-glutamate receptor complex in cortical pyramidal neurons.

Main Results:

  • The serotonin 5-HT(2A) receptor is a target for both LSD-like psychedelics and some atypical antipsychotics.
  • Phencyclidine (PCP)-like drug effects are modulated by serotonin 5-HT(2A) and metabotropic glutamate 2/3 receptors.
  • A specific serotonin-glutamate receptor complex is implicated as a potential target for both psychedelic and antipsychotic medications.

Conclusions:

  • A unified serotonin-glutamate receptor complex may be the target for psychedelics and atypical/glutamate antipsychotic drugs.
  • Understanding these receptor mechanisms could unify the serotonin and glutamate neurochemical hypotheses of schizophrenia.
  • This research opens avenues for novel therapeutic approaches to schizophrenia treatment.