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Related Experiment Video

Updated: Jun 25, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Microbubbles as a novel contrast agent for brain MRI.

Jerry S Cheung¹, April M Chow, Hua Guo

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong, China.

|March 10, 2009

Summary

Gas-filled microbubbles show promise as MRI contrast agents for the brain. Studies in rats demonstrate their effectiveness in enhancing MRI signals, paving the way for new neurological applications.

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Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

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Published on: June 12, 2021

Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound

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Published on: March 4, 2015

Area of Science:

Magnetic Resonance Imaging (MRI)
Biomedical Engineering
Nanotechnology

Background:

Gas-filled microbubbles possess unique magnetic susceptibility properties.
Their biocompatibility and ultrasound-responsive nature make them suitable for biomedical applications.
Microbubbles offer potential as novel contrast agents for Magnetic Resonance Imaging (MRI).

Purpose of the Study:

To evaluate the efficacy of gas-filled microbubbles as intravascular contrast agents for in vivo dynamic brain MRI.
To compare the performance of custom-made albumin-coated microbubbles (A-MB) with a commercial agent (SonoVue).
To investigate the potential of microbubbles for real-time MRI guidance in central nervous system therapies.

Main Methods:

In vivo dynamic brain MRI was performed at 7 Tesla in Sprague-Dawley rats.
Two types of microbubbles, A-MB and SonoVue, were administered intravenously.
Transverse relaxation rate enhancements (DeltaR(2)(*)) were measured and mapped in the brain.

Main Results:

Both A-MB and SonoVue demonstrated significant transverse relaxation rate enhancements in the rat brain.
Calculated DeltaR(2)(*) values were comparable between the two microbubble types.
Brain DeltaR(2)(*) maps showed similarities to cerebral blood volume maps obtained with conventional agents.

Conclusions:

Gas-filled microbubbles can function as effective intravascular contrast agents for high-field brain MRI.
This technology holds potential for advancing microbubble-based drug delivery and therapeutic interventions in the CNS.
Microbubbles may enable real-time MRI guidance for neurological treatments.