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Updated: Jun 25, 2026

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
Physically active lifestyle does not decrease the risk of fattening
Klaas R Westerterp1, Guy Plasqui
1Department of Human Biology, Maastricht University, Maastricht, The Netherlands. K.Westerterp@HB.Unimaas.NL
As people age, reduced physical activity leads to increased body fat. Maintaining energy balance requires conscious dietary changes to offset lower activity levels, especially in young adults.
Area of Science:
- Gerontology
- Human Physiology
- Nutritional Science
Background:
- Aging is linked to decreased physical activity and increased body fat.
- Reduced physical activity impacts energy balance and fat storage.
- Understanding age-related changes in physical activity is crucial for health.
Purpose of the Study:
- To investigate the effects of age-associated physical activity decline on energy balance.
- To determine how reduced physical activity influences body fat accumulation.
- To examine the relationship between physical activity changes and fat gain in young adults.
Main Methods:
- Longitudinal observation of young adults over 10+ years.
- Measurement of physical activity using doubly labeled water and accelerometers.
- Assessment of body fat gain via isotope dilution techniques.
Main Results:
- A significant correlation was found between changes in physical activity and body fat.
- Higher initial physical activity levels predicted greater fat gain over time.
- Reduced physical activity in young adulthood contributes to increased adiposity.
Conclusions:
- Transitioning to a sedentary lifestyle does not automatically decrease energy intake.
- Cognitive control and dietary adjustments are necessary to maintain energy balance with reduced physical activity.
- Interventions may be needed to manage fat gain associated with lifestyle changes.
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