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[Errors in lavage therapy in diffuse peritonitis].

M Imhof1

  • 1Chirurgische Universitätsklinik, Würzburg.

Zentralblatt Fur Chirurgie
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Alkalizing the abdominal cavity stops septic reactions in severe peritonitis. This novel treatment involves continuous lavage with sodium bicarbonate, improving outcomes in surgical patients.

Area of Science:

  • Surgical infections
  • Peritoneal disease
  • Biochemistry

Context:

  • Suppurative peritonitis remains a significant surgical challenge.
  • Bacterial and endotoxin presence triggers complex, often unknown, inflammatory cascades.
  • The terminal biochemical reactions in severe peritonitis occur in an acidic pH environment.

Purpose:

  • To investigate the effect of intraperitoneal alkalization on septic reactions in peritonitis.
  • To explore a novel treatment strategy for severe peritonitis by altering peritoneal pH.

Summary:

  • Experiments demonstrated that increasing the intraperitoneal pH to physiological levels or higher halts septic reactions.
  • A new treatment protocol for severe peritonitis was implemented, including focus sanitation and continuous abdominal lavage with saline and sodium bicarbonate to achieve a pH of 7.6.

Related Experiment Videos

  • The protocol involves open abdominal management with daily revisions and lavage.

    • Impact:

    • Early clinical data suggest this alkalization strategy supports experimental findings.
    • This approach offers a potential new therapeutic avenue for managing severe peritonitis.
    • Further clinical data are needed to fully validate the efficacy of this treatment.