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Updated: Jun 25, 2026

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
Published on: March 26, 2018
LRP-1: a new modulator of cytoskeleton dynamics and adhesive complex turnover in cancer cells
Stéphane Dedieu1, Benoit Langlois
1Université de Reims Champagne-Ardenne (URCA), CNRS UMR MEDyC 6237, Laboratoire SiRMa, Reims, France. stephane.dedieu@univ-reims.fr
Abstract:
The low-density lipoprotein receptor-related protein-1 (LRP-1)is a large scavenger receptor mediating the internalization and catabolism of various biological components from the extracellular matrix. In the past decade, LRP-1 appeared as an attractive receptor for targeting the invasive behavior of cancer cells since this protein is able to reduce the accumulation of extracellular proteinases by endocytosis. However, recent data suggest that LRP-1 could support carcinoma cell invasion depending on the cellular environment. Indeed, in addition to its well-determined role in ligand binding and endocytosis, LRP-1 emerges as a central molecular regulator of cytoskeleton organization and adhesive complex turnover in malignant cells. This commentary reviews the functions played by LRP-1 in cancer-related events and discusses the potential mechanisms whereby LRP-1 is able to control the cellular phenotype of cancer cells.
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