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Abnormal expression of galectins and their correlation with fibrogenesis in adenomyosis
Yuan Zhou1, Mengdong Cao1, Zhenzhen Wang2
1Department of Gynaecology and Obstetrics, Xiangyang No.1 People's Hospital Graduate Joint Training Base, School of Medicine, Wuhan University of Science and Technology, Xiangyang, P.R. China.
Abstract:
This cross-sectional study investigated galectin-1, -3, and -9 in adenomyosis. Analysis of hysterectomy tissues from premenopausal women via western blot, qPCR, immunohistochemistry, and Masson's staining revealed significantly elevated galectin levels compared to controls. Galectin expression positively correlated with fibrosis severity (r = 0.476, 0.925, 0.563, all p < .05), which in turn moderately correlated with dysmenorrhea (VAS score) and uterine enlargement. Findings indicate that galectins are implicated in adenomyosis-related fibrosis and pain, suggesting their potential as therapeutic targets.
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