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Updated: Jun 25, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Adherence to emergency department discharge prescriptions
Corinne M Hohl1, Riyad B Abu-Laban, Jeffrey R Brubacher
1Department of Emergency Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada. chohl@interchange.ubc.ca
Nearly 40% of patients discharged from the emergency department (ED) show medication nonadherence. Antibiotic prescriptions were linked to better adherence, but adverse drug events and multiple medications may increase nonadherence risks.
Area of Science:
- Pharmacology
- Health Services Research
- Patient Adherence
Background:
- Medication nonadherence significantly increases patient morbidity, mortality, and healthcare utilization.
- Effective strategies are needed to improve medication adherence in patients discharged from emergency settings.
Purpose of the Study:
- To determine the rates of prescription-filling and medication adherence among patients after emergency department (ED) discharge.
- To identify factors associated with medication nonadherence in this patient population.
Main Methods:
- A prospective, observational study was conducted in a Canadian tertiary care ED.
- Prescription-filling was assessed via a provincial database 2 weeks post-discharge.
- Patient interviews evaluated adherence, adverse drug-related events (ADREs), and unplanned healthcare revisits.
Main Results:
- Of 258 participants, 19.8% failed to fill prescriptions and 40.3% were nonadherent to at least one medication.
- Antibiotic prescriptions correlated with lower nonadherence (OR 0.21).
- Trends indicated higher nonadherence with ADREs (OR 1.84) and multiple coprescribed medications (OR 1.71). Nonadherent patients showed a trend toward increased revisits (OR 1.75).
Conclusions:
- Approximately 40% of ED-discharged patients exhibit medication nonadherence.
- Prescribing antibiotics may improve adherence.
- Further research is warranted on nonadherence links to ADREs, polypharmacy, and healthcare service use.
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