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Published on: October 25, 2024
Synthesis and antitubercular screening of imidazole derivatives
Jyoti Pandey1, Vinod K Tiwari, Shyam S Verma
1Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India.
Abstract:
A series of imidazole based compounds were synthesized by reacting simple imidazoles with alkyl halides or alkyl halocarboxylate in presence of tetrabutylammonium bromide (TBAB). The compounds bearing carbethoxy group undergo amidation with different amines in the presence of DBU to give respective carboxamides. The synthesized compounds were screened against Mycobacterium tuberculosis where compound 17 exhibited very good in vitro antitubercular activity and may serve as a lead for further optimization.
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