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Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...

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Updated: Jun 25, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Published on: January 7, 2019

Imaging in multiple myeloma.

Stefan Delorme1, Andrea Baur-Melnyk

  • 1German Cancer Research Center (DKFZ), Department of Radiology, E 010 Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. s.delorme@dkfz.de

European Journal of Radiology
|March 11, 2009
PubMed
Summary
This summary is machine-generated.

Imaging in multiple myeloma is crucial for staging and fracture risk. MRI excels at detecting diffuse bone marrow involvement and tumors, while whole-body low-dose CT (WBCT) offers advantages over plain films but struggles with certain lesions.

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Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Multiple myeloma diagnosis and staging traditionally rely on imaging to assess disease extent and predict skeletal complications.
  • Evolving staging systems incorporate advanced imaging modalities beyond plain films, recognizing their superior sensitivity.

Purpose of the Study:

  • To evaluate the role and comparative effectiveness of different imaging techniques in multiple myeloma.
  • To highlight the strengths and limitations of MRI, whole-body low-dose CT (WBCT), and PET/CT in detecting myeloma-related bone disease.

Main Methods:

  • Review of current imaging practices in multiple myeloma.
  • Comparison of sensitivity and specificity for detecting bone lesions across MRI, WBCT, and PET/CT.
  • Assessment of imaging utility in staging and monitoring treatment response.

Main Results:

  • MRI is highly sensitive for diffuse bone marrow infiltration and solid plasma cell tumors.
  • Whole-body low-dose CT (WBCT) is faster and more sensitive than plain films but has limitations in detecting intramedullary lesions within fatty long bones and diffuse/intravertebral infiltration without bone destruction.
  • FDG-PET/CT is less sensitive to diffuse marrow infiltration but useful for assessing treatment response in solid tumors with high baseline uptake.

Conclusions:

  • Advanced imaging, particularly MRI, offers significant advantages over traditional methods for multiple myeloma staging.
  • WBCT shows promise as a replacement for plain films but requires careful interpretation for specific lesion types.
  • PET/CT has a role in evaluating treatment response for specific myeloma manifestations.