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Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory organs,...
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.
Non-gated Ion Channels01:24

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism.

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Related Experiment Video

Updated: Jun 25, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

The integrative function of TRPC channels.

Kirill Kiselyov1, Randen L Patterson

  • 1Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA. kiselyov@pitt.edu

Frontiers in Bioscience (Landmark Edition)
|March 11, 2009
PubMed
Summary
This summary is machine-generated.

Transient Receptor Potential Channels (TRPC) are crucial for cellular functions like vascular tone and kidney filtration. Their polymodal regulation explains diverse tissue-specific calcium signaling pathways.

More Related Videos

Purification of Endogenous Drosophila Transient Receptor Potential Channels
08:39

Purification of Endogenous Drosophila Transient Receptor Potential Channels

Published on: December 28, 2021

Related Experiment Videos

Last Updated: Jun 25, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

Purification of Endogenous Drosophila Transient Receptor Potential Channels
08:39

Purification of Endogenous Drosophila Transient Receptor Potential Channels

Published on: December 28, 2021

Area of Science:

  • Molecular Biology
  • Cell Physiology
  • Biophysics

Background:

  • Transient Receptor Potential Canonical (TRPC) channels are homologous to Drosophila TRP channels.
  • TRPC channels are activated by plasma membrane receptors coupled to phospholipase C, mediating calcium influx.
  • TRPC channel activity is vital for vascular tone, kidney filtration, acrosomal reaction, and pheromone recognition.

Purpose of the Study:

  • To synthesize current literature on TRPC channel functions and phenomenology.
  • To focus on the activation and modulatory mechanisms of TRPC channels.
  • To explain tissue-specific TRPC channel behavior through polymodal regulation.

Main Methods:

  • Literature synthesis and review.
  • Analysis of TRPC channel activation pathways.
  • Examination of TRPC channel modulation by covalent modification, auxiliary proteins, and lipid environment.

Main Results:

  • TRPC channels form homo- and hetero-tetramers, creating diverse channel properties.
  • TRPC channels integrate various stimuli via multiple modulatory inputs.
  • Polymodal regulation allows for differentiated calcium signaling in specific tissues.

Conclusions:

  • TRPC channel activity is implicated in numerous physiological processes.
  • The complex activation and modulation of TRPC channels are key to their diverse roles.
  • Polymodal regulation of TRPC channels likely underlies their specific functions in different tissues.