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Perspectives in PML: a unifying framework for PML function.

Katherine L B Borden¹, Biljana Culjkovic

¹Institute for Research in Immunology and Cancer and Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec, H4M 1J6 Canada. katherine.borden@umontreal.ca

Frontiers in Bioscience (Landmark Edition)

|March 11, 2009

Summary

The promyelocytic leukemia (PML) protein regulates cell growth, apoptosis, and DNA repair. This review proposes a model where PML

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Area of Science:

Cellular Biology
Molecular Biology
Oncology

Background:

The promyelocytic leukemia (PML) protein exhibits diverse functions including proliferation repression, apoptosis promotion, and senescence induction.
Loss of PML or its nuclear bodies is linked to various human diseases.
PML influences critical cellular processes like mRNA export, DNA repair, Akt signaling, p53/Mdm2 activity, and cell cycle progression.

Purpose of the Study:

To propose a unifying molecular model for PML protein function.
To explore how PML's post-transcriptional gene regulation contributes to its broad physiological effects.

Main Methods:

This is a review article, thus no specific experimental methods were employed.
Literature review and theoretical modeling of PML protein functions.

Main Results:

A molecular model is postulated to unify the disparate activities of the PML protein.
PML's ability to coordinately and combinatorially regulate gene expression post-transcriptionally is highlighted as a key mechanism.

Conclusions:

The proposed model offers a potential unifying framework for understanding PML's diverse roles in cellular physiology.
Post-transcriptional gene regulation by PML is a critical determinant of its wide-ranging cellular effects.