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Enhancing oxygen solubility using hemoglobin- and perfluorocarbon-based carriers.

Valerie Centis¹, Patrick Vermette

¹Laboratoire de Bioingenierie et de Biophysique de , Universite de Sherbrooke, Department of Chemical Engineering, Universite de Sherbrooke, 2500, boul. de l'Universite, Sherbrooke, Quebec, Canada, J1K 2R1.

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Summary

This review compares hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon-based (PFC) oxygen carriers for improving oxygen supply in cell and tissue cultures, detailing their properties, preparation, and associated benefits and drawbacks.

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Area of Science:

Biomedical Engineering
Biotechnology
Biochemistry

Background:

Effective oxygen supply is crucial for cell and tissue culture viability.
Current methods face limitations in oxygen transport and transfer efficiency.
Novel oxygen carriers are needed to overcome these challenges.

Purpose of the Study:

To review and compare two main approaches for enhanced oxygen transport: hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon-based (PFC) oxygen carriers.
To discuss recent developments and properties of these oxygen carriers.
To highlight the advantages and disadvantages of each approach.

Main Methods:

Literature review of modified hemoglobin-based oxygen carriers (HBOCs) and their preparation.
Review of advances in perfluorocarbon-based (PFC) oxygen carriers.
Comparative analysis of the properties, benefits, and pitfalls of both HBOCs and PFCs.

Main Results:

Detailed overview of various HBOC types and their preparation methods.
Summary of recent advancements in PFC oxygen carrier technology.
Identification of key advantages and limitations for both HBOCs and PFCs based on existing literature.

Conclusions:

Both HBOCs and PFCs offer potential solutions for enhancing oxygen supply in cell and tissue cultures.
Each carrier type presents unique advantages and challenges that require careful consideration for specific applications.
Further research and development are needed to optimize these oxygen carriers for widespread use.