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Crosstalk signaling between mitochondrial Ca2+ and ROS
Robert F Feissner1, Jolanta Skalska, Winston E Gaum
1Mitochondrial Research and Innovation Group and Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA. robert_feissner@urmc.rochester.edu
Frontiers in Bioscience (Landmark Edition)
|March 11, 2009
Summary
Mitochondria manage cellular energy and calcium (Ca2+) signaling. This review explores the balance of mitochondrial Ca2+ and reactive oxygen species (ROS), crucial for cell function and signaling.
Area of Science:
- Cellular Biology
- Mitochondrial Physiology
- Biochemistry
Background:
- Mitochondria are vital for ATP production and cellular Ca2+ signaling.
- Mitochondrial Ca2+ influences ATP synthesis but overload causes dysfunction.
- Reactive oxygen species (ROS) are signaling molecules but also cause oxidative stress.
Purpose of the Study:
- To review mitochondrial Ca2+ uptake and ROS generation.
- To examine the redox modulation of Ca2+ transport proteins.
- To present a model for Ca2+-ROS signaling crosstalk in mitochondria.
Main Methods:
- Literature review of mitochondrial Ca2+ and ROS signaling.
- Analysis of data on Ca2+ transport and ROS production.
- Development of a conceptual model for signaling crosstalk.
Main Results:
- Mitochondrial Ca2+ uptake is critical for energy metabolism and Ca2+ dynamics.
- ROS generated during ATP production have dual roles in signaling and damage.
- A complex interplay exists between Ca2+ and ROS in cellular microdomains.
Conclusions:
- Maintaining a balance of mitochondrial Ca2+ and ROS is essential for cell health.
- Crosstalk between Ca2+ and ROS pathways influences mitochondrial function.
- Understanding these interactions is key to addressing mitochondrial dysfunction.
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