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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Frequency-dependent Selection01:21

Frequency-dependent Selection

When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.Positive Frequency-Dependent SelectionIn positive...
Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.In the early 20th century,...
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
What is Natural Selection?01:32

What is Natural Selection?

Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.The Theory of Natural...
Natural Selection and Mating Preferences01:06

Natural Selection and Mating Preferences

The principle of natural selection posits that organisms better adapted to their environment are more likely to survive and reproduce. This principle is closely intertwined with mating preferences, a key aspect of sexual selection, which evolutionary psychologists believe is driven by instincts to propagate one's genes. Such instincts significantly influence mating behaviors and preferences between genders.
Females, due to their biological roles in conception, pregnancy, and nursing, inherently...

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Pooled CRISPR-Based Genetic Screens in Mammalian Cells
09:05

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Published on: September 4, 2019

The GS (genetic selection) Principle.

David L Abel1

  • 1The Gene Emergence Project, The Origin-of-Life Science Foundation, Inc., 113 Hedgewood Dr. Greenbelt, MD 20770-1610 USA. life@us.net

Frontiers in Bioscience (Landmark Edition)
|March 11, 2009
PubMed
Summary
This summary is machine-generated.

The Genetic Selection (GS) Principle proposes that biological selection occurs at the molecular-genetic level of nucleotide sequencing, not just organism survival. This fundamental process governs genetic algorithms and polynucleotide coding for all life.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Evolutionary Biology

Background:

  • Ordinary natural selection acts on existing organisms.
  • This does not fully explain the origin of genetic coding and polynucleotide sequences.
  • Epigenetic factors are also guided by underlying genetic programming.

Purpose of the Study:

  • To introduce the Genetic Selection (GS) Principle.
  • To differentiate between selection for existing function and selection for potential function.
  • To propose a molecular-level basis for biological selection.

Main Methods:

  • Conceptual framework based on molecular-genetic processes.
  • Analysis of nucleotide selection as a fundamental mechanism.
  • Analogy to formal selection at binary logic gates and switch settings.

Main Results:

  • Biological selection fundamentally occurs at the nucleotide-sequencing level (3'5' phosphodiester bond formation).
  • Genetic algorithms and polynucleotide coding are directed by this molecular-level selection.
  • This selection precedes the establishment of integrated biological functions.

Conclusions:

  • The GS Principle redefines biological selection as a process at the molecular-genetic level.
  • Selection for potential function, occurring at nucleotide decision points, is distinct from natural selection.
  • This principle offers a new perspective on the origins of genetic information and biological complexity.