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Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow
Published on: July 15, 2016
Porcine mesenchymal stem cells--current technological status and future perspective
Gyu Jin Rho1, B Mohana Kumar, S S Balasubramanian
1Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Republic of Korea. jinrho@gnu.ac.kr
Frontiers in Bioscience (Landmark Edition)
|March 11, 2009
Summary
Porcine mesenchymal stem cells (MSCs) are valuable models for human cell research. Their differentiation, immunomodulatory capacity, and potential in nuclear transfer offer significant promise for medicine and biopharming.
Area of Science:
- Stem Cell Biology
- Regenerative Medicine
- Comparative Biology
Background:
- Porcine mesenchymal stem/progenitor cells (MSCs) share similarities with human counterparts.
- These similarities position porcine MSCs as a valuable model for in vitro studies and preclinical assessments.
Purpose of the Study:
- To review recent findings on porcine MSCs.
- To highlight their sources, differentiation capabilities, transplantation applications, and potential in somatic cell nuclear transfer.
Main Methods:
- Review of existing literature on porcine MSCs.
- Analysis of data regarding isolation, expansion, differentiation, and transplantation of porcine MSCs.
Main Results:
- Porcine MSCs can be effectively isolated and expanded from various sources.
- Consistent in vitro differentiation into mesenchymal lineages and evidence of transdifferentiation.
- Preclinical studies show time-dependent retention, engraftment, migration, and differentiation.
- Encouraging findings on immunogenicity and immunomodulatory capacity.
- Suitability of porcine MSCs as nuclear donors for somatic cell nuclear transfer.
Conclusions:
- Porcine MSCs are a versatile tool for biomedical research and therapeutic development.
- Their potential extends to regenerative medicine, understanding host compatibility, and biopharming applications.
